Tetrahydrothiopyran-4-one as Five-Carbon Source for Scalable Synthesis of (±)-Tapentadol

 Ramagonolla Kranthikumar

• Prathama S. Mainkar
• Genji Sukumar
• Rambabu Chegondi
• Srivari Chandrasekhar*

The improved process for the synthesis of (±)-tapentadol, the FDA-approved analgesic drug, is achieved from tetrahydrothiopyran-4-one as the five-carbon source.

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