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The role of modern drug discovery in the fight against neglected and tropical...
The role of modern drug discovery in the fight against neglected and tropical diseases Med. Chem. Commun., 2014, Advance Article DOI: 10.1039/C4MD00011K, Review Article Jeremy N. Burrows, Richard L....
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A highly efficient and recyclable ligand-free protocol for the Suzuki...
A highly efficient and recyclable ligand-free protocol for the Suzuki coupling reaction of potassium aryltrifluoroborates in water Green Chem., 2014, 16,2185-2189 DOI: 10.1039/C3GC42182A, Paper Leifang...
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Nanoparticles Deliver Three Cancer Drugs To Tumors Drug Delivery: Polymeric...
CANCER KILLER A drug-delivering nanoparticle with cisplatin core (green) is formed by polymerization of doxorubicin- and camptothecin-derivatized monomers and a cisplatin cross-linker....
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One-Two Nanopunch For Difficult-To-Treat Breast Cancer Drug Delivery: Layered...
Double Duty To deliver a one-two nanopunch to triple-negative breast cancer tumors, researchers start with a lipid-coated sphere filled with the chemotherapy drug doxorubicin (left). Then they add...
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Academic−Industrial Partnerships in Drug Discovery and Development
Author: Jonathan Faiz Published: 22 April 2014 Copyright: Wiley-VCH Verlag GmbH & Co. KGaA Source / Publisher: Angewandte Chemie International Edition Associated Societies: Gesellschaft Deutscher...
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More and more companies are using fragment-based lead design as a drug...
shaking hands Small fragments that bind in nearby pockets can be connected to make a lead. In the pursuit of new pharmaceuticals, many medicinal chemists want to start their leg of the drug discovery...
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MIT chemists design nanoparticles that can deliver three cancer drugs at a time.
Targeting Cancer with a Triple Threat | MIT Technology Review MIT chemists design nanoparticles that can deliver three cancer drugs at a time. Delivering chemotherapy drugs in nanoparticle form could...
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5 Things You Should Know About MERS, The Deadly Virus That’s Now Breaking Out...
The MERS virus. MERS (Middle Earth Respiratory Virus) A new spike in cases of a deadly respiratory virus, in Saudi Arabia and the United Arab Emirates, is prompting new fears of an outbreak when the...
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Europe green light for GSK COPD drug Incruse (umeclidinium)
Regulators in Europe have given the green light to GlaxoSmithKline’s new chronic obstructive pulmonary disease drug Incruse. Specifically, the European Commission has granted marketing authorisation...
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Otsuka multi-drug resistant TB drug approved in Europe
Delamanid Otsuka Pharmaceutical Co has been given the green light to sell its tuberculosis drug Deltyba in Europe. Read more at:...
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Antibiotic May Sidestep Resistance, Drug Discovery: Bacteria may find agent’s...
SIDE BY SIDE Rifamycin SV (yellow stick structure) and GE23077 (blue stick structure) bind to adjacent sites on RNA polymerase (red and green). Mesh indicates electron density; purple ball is active...
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Semagacestat
(2S)-2-hydroxy-3-methyl-N-((1S)-1-methyl-2-{[(1S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepin-1-yl]amino}-2-oxoethyl)butanamide 425386-60-3 425386-60-3, LY450139, LY-450139, LY 450139 Molecular...
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Biological Drug Works Against MERS Virus in Lab
This file photo provided by the National Institute for Allergy and Infectious Diseases shows a colorized transmission of the MERS coronavirus that emerged in 2012. Health officials on Friday, May 2,...
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Speedier Route to Antibiotic Core
Improved method offers better access to the core structure of synthetic antibiotics Read more
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Academic−Industrial Partnerships in Drug Discovery and Development
Academic−Industrial Partnerships in Drug Discovery and Development According to K. C. Nicolaou, such a partnership will be essential to apply fundamental chemistry to medicine Read more
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Versatile Capsules
Versatile Capsules Multifunctional microcapsules made from metals and tannic acid Read more
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Gel Filled Filter—More than a Pore
Gel Filled Filter—More than a Pore Microgel-based thermoresponsive membranes for water filtration Read more
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Researchers Discover Novel Molecule to Treat Asthma
Pollen http://www.dddmag.com/news/2014/05/researchers-discover-novel-molecule-treat-asthma
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NMR EXAMPLE
1H NMR (300 MHz; (CD3)2CO) 11.76 (1 H, s, OH (naph.) [exch]), 8.74 (1 H, dd, J 8.5 and 1.0, naph.), 8.10 (1 H, d, J 9.0, naph.), 7.89 (1 H, dd, J 8.5 and 1.5, naph.), 7.86 (1 H, dd, J 6.5 and 2.0,...
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1-((3-methoxyphenyl)sulfonyl)piperidine …learn spectroscopy
1-((3-methoxyphenyl)sulfonyl)piperidine (2) is a crystalline white solid 1-((3-Methoxyphenyl)sulfonyl)piperidine: Piperidine, 1-[(3-methoxyphenyl)sulfonyl]-; (2) cas no (173681-65-7) mp 115-116 °C; 1H...
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