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Kalyan Kumar Pasunooti, 5-Methylisoxazole-3-carboxamide-Directed...
Palladium-catalyzed acetoxylation of the primary γ-C(sp3)–H bonds in the amino acids Val, Thr, and Ile was achieved using a newly discovered 5-methylisoxazole-3-carboxamide directing group. The...
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API, Impurities and Regulatory aspects
The impurities in pharmaceuticals are unwanted chemicals that remain with the active pharmaceutical ingredients (APIs) or develop during formulation or upon aging of both API and formulation. The...
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Carbanio – a digital B2B platform to buy and sell Chemicals in India
Hello All I have an exciting news which I want to share today. Couple of days ago, I was browsing on the internet to see if we can buy ready stock of Chemicals online, especially from Indian Suppliers....
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Latest artificial glucose-binding receptor is best yet
It’s a receptor that binds glucose strongly and with the highest selectivity yet. Could help with #diabetes treatment: http://ow.ly/EPzn30mDYjf Read all at...
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Use of Lipase Catalytic Resolution in the Preparation of Ethyl...
Here we describe an efficient and cost-effective chemoenzymatic synthesis of the β-lactamase inhibitor avibactam starting from commercially available ethyl 5-hydroxypicolinate hydrochloride. Avibactam...
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Anthony Crasto conferred ABPnews award for “Outstanding contribution to...
Conferred prestigious award at event ABP News Presents Healthcare Leadership Awards 26th November, 2018 at Taj Lands End, Mumbai India Dedicated to Shobha Crasto Aishal crasto Lionel crasto Service...
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Article 0
Sodium aluminate is presented as a highly active heterogeneous catalyst that is able to convert a range of alcohols into the corresponding unsymmetrical carbonate esters by reaction with dimethyl...
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(1S,4R)-2-(4-Methoxybenzoyl)bicyclo[2.2.2]octa-2,5-diene
(1S,4R)-2-(4-Methoxybenzoyl)bicyclo[2.2.2]octa-2,5-diene (3a) Yellow liquid (25.2 mg, 95% yield): 1H NMR (300 MHz, CDCl3) 1.39 (s, 4H, alkyl), 3.77-3.80 (m, 1H, alkyl), 3.85 (s, 3H, OMe), 4.36 (d,...
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Orochem Molecular Purification by Design
Established in 1996, Orochem Technologies Inc. started as a Biotech and Chromatography company to manufacture unique Sample Prep Technology “Products” for the Bioanalysis, Drug Discovery, and the...
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Combination of Enantioselective Preparative Chromatography and Racemization:...
Conventional enantioselective preparative chromatographic separation using columns packed with chiral stationary phase is characterized by a 50% yield constraint. Racemization of the undesired...
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General Pharmacology
Top 20 General Pharmacology Questions Every one of us Should Know *Q.1 What is Pharmacology?* Ans: Pharmacology is a branch of science that deals with the interaction of drugs with living organisms....
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Kalyan Kumar Pasunooti, Novel Tetrazole-Containing Analogues of Itraconazole...
Itraconazole has been found to possess potent antiangiogenic activity, exhibiting promising antitumor activity in several human clinical studies. The wider use of itraconazole in the treatment of...
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Large scale synthesis of chiral (3Z,5Z)-2,7-dihydro-1H-azepine-derived Hamari...
(R)-2,2′-bis(bromomethyl)-1,1′-binaphthalene ((R)-17) was prepared in the identical manner and had identical analytical properties to those given here. 1H NMR (400 MHz, CDCl3): δ 4.25 (4H, s, 2 ×...
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Photo-organocatalytic synthesis of acetals from aldehydes
Abstract A mild and green photo-organocatalytic protocol for the highly efficient acetalization of aldehydes has been developed. Utilizing thioxanthenone as the photocatalyst and inexpensive household...
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Eco-friendly decarboxylative cyclization in water: practical access to the...
Abstract An environmentally benign decarboxylative cyclization in water has been developed to synthesize 4-quinolones from readily available isatoic anhydrides and 1,3-dicarbonyl compounds. Isatins...
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A solvent-free catalytic protocol for the Achmatowicz rearrangement
Abstract Reported here is the development of an environmentally friendly catalytic (KBr/oxone) and solvent-free protocol for the Achmatowicz rearrangement (AchR). Different from all previous methods...
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Nickel-catalyzed regioselective C–H oxygenation: new routes for versatile C–O...
Nickel-catalyzed regioselective C–H oxygenation: new routes for versatile C–O bond formation Org. Chem. Front., 2019, Advance Article DOI: 10.1039/C8QO01274A, Research Article Ze-lin Li, Kang-kang...
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Telescoped Sequence of Exothermic and Endothermic Reactions in Multistep Flow...
A multistep sequential flow synthesis of isopropyl phenol is demonstrated, involving 4-step exothermic, endothermic, and temperature sensitive reactions such as nitration, reduction, diazotization,...
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Structural evolution of carbon in an Fe@C catalyst during the Fischer–Tropsch...
Structural evolution of carbon in an Fe@C catalyst during the Fischer–Tropsch synthesis reaction Shuai Lyu,ab Chengchao Liu,b Guanghui Wang,*a Yuhua Zhang,b Jinlin Lib and Li Wang*b Author...
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Design, synthesis and antimicrobial activity of usnic acid derivatives
Design, synthesis and antimicrobial activity of usnic acid derivatives Victor Kartsev,a Boris Lichitsky,b Athina Geronikaki,*c Anthi Petrou,c Marija Smiljkovic,d Marina Kostic,d Oliver...
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