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Lexipafant
Lexipafant CAS : 139133-26-9 N-Methyl-N-[[4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]phenyl]sulfonyl]-L-leucine ethyl ester...
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Arterolane maleate a Ranbaxy NCE set to conquer Malaria
Arterolane cas 664338-39-0, UNII-3N1TN351VB, OZ277, RBX-11160, NCGC00274173-01 Molecular Formula: C22H36N2O4 Molecular Weight: 392.53224 Medicines For Malaria Venture Mmv Ranbaxy Lab Ltd innovator...
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(S)-(+)-3-HYDROXY-2,2-DIMETHYLCYCLOHEXANONE
(S)-(+)-3-hydroxy-2,2-dimethylcyclohexanone bp 85–87°C at 3.7 mm, [α]21D + 23.0° (CHCl3, c 2.0) The spectral properties of (S)-(+)-3-hydroxy-2,2-dimethylcyclohexanone are as follows: IR vmax...
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Piece by Piece A guide to fragment-based drug discovery
DESIGNING A BETTER DRUG: The combination of chemical groups from three different fragments that bind weakly to an enzyme produce a potent new enzyme inhibitor (center) that binds in the nM...
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5-hydroxy-4-keto-pentenoic acid (HKPA).
C. Oliver Kappe, University of Graz, Austria, and colleagues prepared for the first time the potential new platform molecule H2MF in pure form and converted it to the polyester precursor...
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CMI 977, LDP 977
CMI 977 C16-H19-F-N2-O4 322.3341 Millennium (Originator), Taisho (Licensee) (2S,5S)-1-[4-[5-(4-Fluorophenoxymethyl)tetrahydrofuran-2-yl]-3-butynyl]-1-hydroxyurea 175212-04-1 CMI-977 is a potent...
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Ensuring Process Stability with Reactor Temperature Control Systems
Temperature control plays an important role in industrial processes, pilot plants, and chemical and pharmaceutical laboratories. When controlling reactors, both exothermic and endothermic reactions...
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ANTIMALARIAL PIPELINE
Malaria, a devastating infectious disease caused by Plasmodium spp., leads to roughly 655,000 deaths per year, mostly of African children. To compound the problem, drug resistance has emerged to all...
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An Integrated Synthesis–Purification System to Accelerate the Generation of...
An Integrated Synthesis–Purification System to Accelerate the Generation of Compounds in Pharmaceutical Discovery...
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Meclinertant (SR48692)
2-[[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid Meclinertant (SR-48692) is a drug which acts as a selective, non-peptide antagonist at...
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RUFINAMIDE….FLOW SYNTHESIS
A report (Org Process Res Dev 2014, ASAP article) out of Jamison’s group at MIT, provides a 3-step synthesis of Rufinamide in 92% overall yield. The process illustrates a continuous and convergent...
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DRUGS….FLOW SYNTHESIS
IMAGE……….http://www.laboratorytalk.com/life-sciences-and-clinical-laboratory-equipment/synthesis-systems/flow-chemistry-system-aids-synthesis-of-cns-drugs/404882.article 1………………… Gleevec,...
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Synthesis of Methoxyisopropyl (MIP)-Protected (R)-Mandelonitrile and...
Cyanohydrins are synthetically versatile chiral building blocks in organic synthesis. They can be conveniently synthesized in enantiomerically pure form via chemoenzymatic hydrogen cyanide...
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Oleocanthal for treating pain
“Oleocanthal” is specifically deacetoxydialdehydic ligstroside aglycone, which exists as a single isomer (enantiomer). The (-)-enantiomer is the natural product and has the following chemical formula:...
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Diastereoselective [2+2] Photocycloaddition of a Chiral Cyclohexenone with...
The diastereoselective [2+2] photocycloaddition of ethylene to a chiral cyclohexenone was studied in a continuous flow microcapillary reactor. In all cases examined, the microcapillary reactor gave...
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A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions...
http://pubs.rsc.org/en/Content/ArticleLanding/2015/OB/C4OB02376E#!divAbstract A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions Maria Victoria Rojo,*a...
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Tipifarnib
6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; (R)-(+)-R 115777; Zarnestra; 192185-68-5 zarnestra, 192185-72-1, R115777, R-115777, IND...
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Scaling from Milligrams to 1-2Kg
Dr John Knight Scaling from Milligrams to 1-2Kg see at…………..http://news.scientificupdate.co.uk/index.php?action=social&chash=1c1d4df596d01da60385f0bb17a4a9e0.1201 2 – 3 March 2015 Sheraton...
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Methohexital
Methohexital or methohexitone, (marketed under the brand name Brevital) is a drug which is a barbiturate derivative. It is classified as short-acting, and has a rapid onset of action. It is similar...
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Saudi Patent Office AND GULF ( GCC Patent office)
http://www.gccpo.org/DefaultEn.aspx The Patent Office of the Cooperation Council for the Arab States of the Gulf is delighted to announce launching the electronic filing system for patent applications...
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