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Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic...
The coupling of aromatic moieties with saturated heterocyclic partners is currently an area of significant interest for the pharmaceutical industry. Herein, we present a procedure for the metal-free...
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Putting the Catalyst in Charge of Regioselectivity
Putting the Catalyst in Charge of Regioselectivity Regiodivergent pathways of rhodium(III)-catalyzed dihydroisoquinolone synthesis Read more...
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Spirooxindoles from Enantioselective Tandem Reactions
Spirooxindoles from Enantioselective Tandem Reactions Catalytic asymmetric construction of 3,3′-spirooxindoles fused with seven-membered rings Read more...
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Synthesis of β-Lapachone
Synthesis of β-Lapachone A potential anticancer agent from the Lapacho tree Read more http://www.chemistryviews.org/details/ezine/6836171/Synthesis_of_-Lapachone.html
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Esoxybutynin, (S)-Oxybutynin
(S)-2-Cyclohexyl-2-phenylglycolic acid 4-diethylaminobut-2-ynyl ester Drug name, 药物名称….. Esoxybutynin, (S)-Oxybutynin Sepracor (Originator) RENAL-UROLOGIC DRUGS, Urinary Incontinence Therapy,...
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Ragaglitazar ……..Dr. Reddy’s Research Foundation
Ragaglitazar NNC-61-0029, (-) – DRF-2725, NN-622, (−)DRF 2725 cas 222834-30-2 222834-21-1 (racemate) Hyperlipidemia; Hypertriglyceridemia; Lipid metabolism disorder; Non-insulin dependent diabetes...
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Zingerone
Zingerone Flower Spice In everyday life, ginger is used in cooking for its hot taste as well as its pungent smell. Ecologists have studied the relationships of food and culture...
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Drug Discovery: Researchers optimize syntheses by adapting coupling reactions...
The Merck group used arrays of coupling reactions to optimize the microgram-scale C–N coupling of an aryl halide (left) with an amine (over arrow) to give an arylamine. They then scaled up the process...
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Ethyl-2-butenoate NMR
Ethyl-2-butenoate 1H-NMR proton decoupled spectrum of Ethyl-2-butenoate in CDCl3. 1H-NMR proton coupled spectrum of Ethyl-2-butenoate in CDCl3. 13C-NMR proton decoupled spectrum of...
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LIDOCAINE SPECTRAL VISIT
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide Lidocaine is used in drugs formulated for local anaesthetics. MW= 234.34 g/mol; MP= 68-69 o C; bruttoformula: C14H22N2O; CAS-number: 137-58-6;...
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DEXAMETHASONE
-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione; 9-alpha-fluoro-16-alpha-methylprednisolone;...
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QUININE
Quinine Molecular Formula: C20H24N2O2 Molecular Weight: 324.417 IUPAC Name: 6′-Methoxycinchonan-9-ol CAS Number: 56-54-2 PubChem: 1065 NMRShiftDB: 10016314 Spectrometer: Bruker AV 400 MHz Probe: 1mm...
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A route to convert CO2: synthesis of 3,4,5-trisubstituted oxazolones
Green Chem., 2015, Advance Article DOI: 10.1039/C4GC02033B, Paper Jiayin Hu, Jun Ma, Zhaofu Zhang, Qinggong Zhu, Huacong Zhou, Wenjing Lu, Buxing Han CO2 can react with various propargylic amines...
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Pimobendan
Pimobendan CAS: 74150-27-9 3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone...
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SPIN SPIN COUPLING
The source of spin-spin coupling The 1H-NMR spectra that we have seen so far (of methyl acetate and para-xylene) are somewhat unusual in the sense that in both of these molecules, each set of protons...
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Which Pharmas Spend the Most on R&D?
Which Pharmas Spend the Most on R&D? Pharmas and biotechs have spent $1 trillon on R&D over the last decade. By Kathlyn Stone Pharma Expert...
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New novel method to twist molecule
The new helical molecule (right) was due to the different length strands (blue and gray) a spatial arrangement of a (schematized in the middle), similar to the railing of a spiral staircase (left)....
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Evaluation of antispasmodic activity of different Shodhit guggul using...
Evaluation of antispasmodic activity of different Shodhit guggul using different shodhan process Rachana Kamble, Sadhana Sathaye, DP Shah University Institute of Chemical Technology, N. Parekh Marg,...
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RABEPRAZOLE SPECTRAL VISIT
1H NMR RABEPRAZOLE RAB standard: (DMSOd6 400 MHz) δ 8.28 (d, 1H, J=5.56 Hz), 7.46 (m, 2H), 6.93 (d, 1H, J=5.68 Hz), 6.88 (m, 2H), 4.57 (AB, 2H, J=12.88 Hz), 4.10 (t, 2H, J=6.19 Hz),...
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Dithiocarbamates: Reagents for the Removal of Transition Metals from Organic...
Dithiocarbamates: Reagents for the Removal of Transition Metals from Organic Reaction Media http://pubs.acs.org/doi/abs/10.1021/op500336h William P. Gallagher * and Anh Vo Chemical Development,...
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