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Mastoparan
Mastoparan, Peptide (H-INLKALAALAKKIL-NH2) IUPAC Condensed H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-xiIle-Leu-NH2 LINUCS...
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Febuxostat
Febuxostat Febuxostat; 144060-53-7; Uloric; Adenuric; Tei 6720; 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid; Molecular Formula: C16H16N2O3S Molecular Weight: 316.37484 g/mol...
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Nickel-Catalyzed Decarbonylative Suzuki–Miyaura Coupling of Amides To...
Shi et al. have reported a nickel-catalyzed decarbonylative Suzuki–Miyaura reaction which uses an N-aroylpiperidine-2,6-dione as the coupling partner for the boronic acid ( Angew. Chem., Int. Ed....
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TEZACAFTOR, VX 661 for treatment of cystic fibrosis disease.
TEZACAFTOR, VX 661 CAS : 1152311-62-0; Molecular FormulaC26H27F3N2O6 Average mass520.498 Da...
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OSILODROSTAT for Treatment of Cushing’s Syndrome
OSILODROSTAT LCI 699, LCI 699NX Novartis Ag INNOVATOR UNII-5YL4IQ1078, CAS 928134-65-0 Benzonitrile, 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluoro-...
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Multicomponent reactions: A simple and efficient route to heterocyclic...
. Multicomponent reactions: A simple and efficient route to heterocyclic phosphonates Mohammad Haji Beilstein J. Org. Chem. 2016, 12, 1269–1301. published 21 Jun 2016 Chemistry Department, Science and...
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Stereoselective synthesis of tricyclic compounds by intramolecular...
. Stereoselective synthesis of tricyclic compounds by intramolecular palladium-catalyzed addition of aryl iodides to carbonyl groups Freie Universität Berlin, Institut für Chemie und Biochemie,...
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QbD in Pharma Development World Congress 2017, SelectBio, 20-21 April, 2017,...
http://selectbiosciences.com/images/DEL_QBD_20Oct.html QbD in Pharma Development World Congress 2017 Registration 3 for 2 Offer SELECTBIO are offering 3 for the price of 2 on all delegate passes. To...
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Reformatsky and Blaise Reactions in Flow as a Tool for Drug Discovery. One...
Compound 3aa was obtained as pale yellow oil (163 mg, 92% yield).MS (ESI): mass calcd. for C12H16O3, 208.1099; m/z found, 209.1102 [M+H] + . 1H NMR (CHLOROFORM-d, 400MHz): δ = 7.45 (d, J=7.7 Hz,...
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Counterfeit of medicines causes 37,000 job losses in EU Pharma Industry
Counterfeit medicine is an increasing problem for public health and economy. This is no longer a problem of certain regions such as Asia and Africa. It has now also become an issue in the EU and US....
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The impact of the FDA Combination Products Guidance on Nasal and Oral...
The FDA draft guidance for combination products has a substantial impact on the development of Oral Inhalation and Nasal Drug Products (OINDPs) as it requires that the manufacturers have to be...
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FDA presentation at the ECA Conference Particles in Parenterals
At the Particles in Parenterals Conference Dr Stephen Langille from the US FDA gave a talk on the FDA’s current thinking with regard to the visual inspection of medicinal products for parenteral use....
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Critical Impurities in Pharmaceutical Water
The quality of the source water used to produce pharmaceutical water plays an important role for both the design of the treatment and the validation of the water system. FDA Warning Letters over the...
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QbD Sitagliptin
Application of On-Line NIR for Process Control during the Manufacture of Sitagliptin George Zhou*, Shane Grosser, Lei Sun, Gabriel Graffius, Ganeshwar Prasad, Aaron Moment, Angela Spartalis,Paul...
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Rush , few seats, ACS INDUSTRY SYMPOSIUM RECENT ADVANCES IN DRUG DEVELOPMENT...
ACS INDUSTRY SYMPOSIUM RECENT ADVANCES IN DRUG DEVELOPMENT IN PARTNERSHIP WITH DR. REDDY’S LABORATORIES HYDERABAD, INDIA 11-12 NOVEMBER 2016 click http://acssymposium.org.in/ for registrations
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Statistical DoE Approach to the Removal of Palladium from Active...
The influence of four parameters (temperature, scavenging time, amount of scavenger, and concentration of palladium in the solution) on the efficiency of Pd removal from a cross-coupling reaction,...
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Prof. K.V. Thomas Endowment International Symposium on New Trends in Applied...
Hearty Welcome to International Symposium, NTAC – 2017 The organizing committee of NTAC – 2017 and The Post Graduate and Research Department of Chemistry, Sacred Heart College (Autonomous),Thevara,...
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EMA/ FDA Mutual Recognition Agreement on drug facility inspections moving...
EMA/ FDA Mutual Recognition Agreement moving forward A possible agreement between the EMA and the US FDA on mutual recognition agreement on drug facility inspections could already be signed in...
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New EDQM’s Public Document informs about the Details required in a New CEP...
A Policy Document recently published by the EDQM describes regulations for referencing already existing CEPs in an application for a new CEP. Read more about how the certificates of an intermediate...
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Opportunities for Reducing Sampling and Testing of Starting Materials
Chapter 5 of the EC GMP Guide for the area of production was updated last year. This chapter contains concrete information about the conditions when testing and sampling of APIs and excipients can be...
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