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Now online – Stimuli article on the proposed USP General Chapter “The...
Now online – Stimuli article on the proposed USP General Chapter “The Analytical Procedure Lifecycle <1220>” A Stimuli Article to the Revision Process regarding the proposed New USP General...
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WO 2016181414, IVACAFTOR, NEW PATENT, COUNCIL OF SCIENTIFIC & INDUSTRIAL...
CSIR, Dr. D. Srinivasa Reddy WO2016181414, PROCESS FOR THE SYNTHESIS OF IVACAFTOR AND RELATED COMPOUNDS...
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Generics: FDA´s New Guidance on Prior Approval Supplements
Generics: The US Food and Drug Administration (FDA) recently published a new Guidance regarding Prior Approval Supplements (PAS). Read more about FDA´s Guidance for Industry “ANDA Submissions – Prior...
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Continuous-Flow Diazotization
Characterization Data of Compound 7 Mp: 118–120 °C. MS (M + H+): 314. HRMS (ESI) m/z: Calcd for C16H15N3NaO4, (M + Na+): 336.0960. Found: 336.0899. IR (KBr) ν/cm–1: 3447, 3339, 1717, 1714, 1699,...
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Enantioselective Borohydride Reduction of Ketones Catalyzed by Optically...
Homogeneous Enantioselective Catalysis in a Continuous-Flow Microreactor: Highly Enantioselective Borohydride Reduction of Ketones Catalyzed by Optically Active Cobalt Complexes Takuo Hayashi†,...
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An Efficient Synthesis of 1-(2-Methoxyphenoxy)-2,3-epoxypropane: Key...
An efficient process for the preparation of 1-(2-methoxyphenoxy)-2,3-epoxypropane, a key intermediate for the synthesis of ranolazine is described. http://pubs.acs.org/doi/suppl/10.1021/op300056k...
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Scientific Update, UK, Course on ‘Chemical Development & Scale Up in the...
Scientific Update, UK, Course on ‘Chemical Development & Scale Up in the Pharmaceutical Industry’, Sea Princess Hotel, Mumbai, India, 6th – 8th February 2017 Want to download Brochure click :View...
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Selection and justification of starting materials: new Questions and Answers...
The ICH Q11 Guideline describing approaches to developing and understanding the manufacturing process of drug substances was finalised in May 2012. Since then the pharmaceutical industry and the...
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How to Extend the Life of a Patent
ALL CREDIT TO WIKIHOW How to Extend the Life of a Patent Three Methods: Determining Eligibility Extending Your Patent Contacting Congress A patent ensures that an inventor is able to profit from his...
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Citarinostat
Citarinostat Treatment of Hematological Malignancies, Molecular Formula, C24-H26-Cl-N5-O3, Molecular Weight, 467.9544, RN: 1316215-12-9 UNII: 441P620G3P...
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Synthesis of 2-[4-(4-Chlorophenyl)piperazin-1-yl]-2-methylpropanoic Acid...
2-[4-(4-Chlorophenyl)piperazin-1-yl]-2-methylpropanoic Acid Ethyl Ester 1-Piperazineacetic acid, 4-(4-chlorophenyl)-α,α-dimethyl-, ethyl ester 2-[4-(4-Chlorophényl)-1-pipérazinyl]-2-méthylpropanoate...
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Synthesis of...
Cas 1204588-48-6 MF C21 H20 N4 O4 MW 392.41 Benzenamine, 2,4-dinitro-N-[(2E,4E)-4-phenyl-5-(1-pyrrolidinyl)-2,4-pentadien-1-ylidene]-, [N(E)]-...
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5-(2-(3-Oxopiperazin-1-yl) propyl)-5,6-dihydropteridin-7(8H)-one
COSY PREDICT 1H NMR PREDICT 1H NMR (DMSO-d6, 400 MHz): δH 0.95 (3H, d, H4), 3.09–3.23 (2H, m, H2), 3.29–3.49 (5H, m, H14, H11, H3), 3.94–4.04 (2H, m,...
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EMA issues new Guideline on “Chemistry of Active Substances”
The new EMA “Guideline on the chemistry of active substances” represents the current state of the art in regulatory practice and fits into the context of the ICH Guidelines Q8-11. Find out what...
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Efficient Transposition of the Sandmeyer Reaction from Batch to Continuous...
The transposition of Sandmeyer chlorination from a batch to a safe continuous-flow process was investigated. Our initial approach was to develop a cascade method using flow chemistry which involved...
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(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol , Furofuranol
CAS : 156928-09-5 Molecular Formula: C6H10O3 Molecular Weight: 130.144 Furo[2,3-b]furan-3-ol, hexahydro-, [3R-(3α,3aβ,6aβ)]- (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol...
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One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive...
One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive amination applying imine reductases Green Chem., 2017, Advance Article DOI: 10.1039/C6GC03023H, Communication P. Matzel, M. Gand,...
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Reflections on Chirality in the Pharmaceutical Industry: Past, Present and...
Christopher Welch New Technologies, Postdoc Program, Science Lead, Analytical Chemistry at Merck christopher_welch@merck.com Reflections on Chirality in the Pharmaceutical Industry: Past, Present and...
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GMP’s for Early Stage Development of new Drug substances and products
GMP’s for Early Stage Development of New Drug substances and products The question of how Good Manufacturing Practice (GMP) guidelines should be applied during early stages of development continues to...
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Highly Selective Phosgene-Free Carbamoylation of Aniline by Dimethyl...
Over the last 20 years organic carbamates have found numerous applications in pesticides, fungicides, herbicides, dyes, pharmaceuticals, cosmetics, and as protecting groups and intermediates for...
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