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Rapamycin (Sirolimus) For the prophylaxis of organ rejection in patients...
Rapamycin (Sirolimus) (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,...
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Glenmark conferred with Best Biotech New Molecular Entity Patent award
GLENMARK PHARMA IDMA best biotech NEW MOLECULAR ENTITY patent award to Glenmark YEAR 2012-2013 YEAR in Mumbai India PATENT US 8236315 GLENMARK PHARMACEUTICALS, S.A., SWITZERLAND INVENTORS Elias...
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Valspodar, PSC-833
Valspodar, SDZ-PSC-833, PSC-833, Amdray P-Glycoprotein (MDR-1; ABCB1) Inhibitors , Multidrug Resistance Modulators Valspodar is a cyclosporine derivative and a P-glycoprotein inhibitor currently in...
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JAPAN…..Takeda wins Japanese OK for Adcetris
Takeda’s Adcetris (brentuximab vedotin) has been given the regulatory go-head in Japan to treat malignant lymphoma. More specifically, the Japanese Ministry of Health, Labour and Welfare (MHLW) has...
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Oncolytic Drugs …Preparation of...
Patents– EP2111401B1 1036712-77-2 cas NO see also WO 2008079968 BAYER VEGFR-2 (FLK-1/KDR) Inhibitors Bcr-Abl Kinase Inhibitors HGFR (MET; c-Met) Inhibitors Inhibitors of protein kinases, such as...
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ARAB MEDICINE- REVIEW
ARAB MEDICINE- REVIEW In the history of medicine, Islamic medicine, Arabic medicine, Greco-Arabic and Greco-Islamic refer to medicine developed in the Islamic Golden Age, and written in Arabic, the...
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Clazosentan
Clazosentan IUPAC Name: N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl) pyridin-4-yl]pyrimidin-4-yl]-5-methylpyridine-2-sulfonamide 5-methyl-pyridine-2-sulphonic acid...
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BELINOSTAT, FAST TRACK, ORPHAN DRUG, A hydroxamate-type inhibitor of histone...
Belinostat (PXD101) PHASE 2, FAST TRACK FDA , ORPHAN STATUS PDX101 PX 105684 PXD-101 PXD101 UNII-F4H96P17NZ Belinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM, with activity...
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Panobinostat
Panobinostat HDAC inhibitors, orphan drug cas 404950-80-7 2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylamide...
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VORINOSTAT
Vorinostat Zolinza, SAHA, suberoylanilide hydroxamic acid, Suberanilohydroxamic acid, N-hydroxy-N’-phenyloctanediamide US patent 5369108, PDT PATENT For the treatment of cutaneous manifestations in...
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Tezosentan disodium for pulmonary hypertension
TEZOSENTAN 180384-57-0 CAS OF FREE ACID N-[6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-propan-2-ylpyridine-2-sulfonamide...
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AVANAFIL
AVANAFIL A phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction. Avanafil is a new phosphodiesterase-5 inhibitor that is faster acting and more selective than other drugs belonging...
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DOXOFYLLINE
DOXOFYLLINE LAUNCHED 1987, Istituto Biologico Chemioterapico ABC 69975-86-6 CAS NO 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione 1H-Purine-2,6-dione,...
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DOLUTEGRAVIR
Dolutegravir 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)...
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Risk Assessment of Genotoxic Impurities in Marketed Compounds Administered...
Controlling impurities during drug development improves product quality and minimizes safety risks to the patient. Recent regulatory guidance on genotoxic impurities (GTIs) state that identified GTIs...
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Dasantafil for Treatment of Erectile Dysfunction
Dasantafil 569351-91-3 CAS NO 405214-79-1 (racemate) UNII-48P711MI2G, SCH 446132, D03657, Molecular Formula: C22H28BrN5O5 Molecular Weight: 522.39222 Merck & Co. (Originator) IN PHASE 2 THERAPEUTIC...
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Prediction of Drug Degradation Pathways leading to Structural Alerts for...
An in-depth analysis of the web-based CambridgeSoft Pharmaceutical Drug Degradation Database, Pharma D3, was conducted in two phases in an attempt to generate some general rules for the prediction of...
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Lodenafil Carbonate … an Erectile Dysfunction Drug in Phase III
Lodenafil carbonate UNII-29X84F932D, CRIS-031 bis-(2-{4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-benzenesulfonyl]piperazin-1-yl}-ethyl)carbonate...
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VARDENAFIL
VARDENAFIL 224785-90-4 CAS NO Vardenafil hydrochloride (CAS NO.224785-91-5) Formula C23H32N6O4S Mol. mass 488.604 g/mol...
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TAKEDA PHARMACEUTICALS 武田薬品工業株式会社 ON THE RISE
Tadataka Yamada, M.D., Chief Medical & Scientific Officer of Takeda TAKEDA US CHICAGO OFFICE TAKEDA PIPELINE SEE LINKS BELOW 1...
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