A novel approach to access ortho iodinated phenols using cyclic hypervalent iodine reagents through palladium(II) catalyzed C–H activation has been developed through weak coordination. The reaction showed excellent regioselectivity, reactivity and good functional group tolerance. A unique mechanism was proposed.

Pd(II) catalyzed ortho C–H iodination of phenylcarbamates at room temperature using cyclic hypervalent iodine reagents

Xiuyun Sun,^a   Xia Yao,^a   Chao Zhang^a and   Yu Rao*^a

*Corresponding authors

^aMOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing 100084, China

E-mail: yrao@mail.tsinghua.edu.cn

Chem. Commun., 2015,51, 10014-10017

DOI: 10.1039/C5CC02533H

http://pubs.rsc.org/en/content/articlelanding/2015/cc/c5cc02533h#!divAbstract

yu rao

Zhang Chao

 Tsinghua University, Beijing

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