Clik here to view.
The rapid synthesis of oxazolines and their heterogeneous oxidation to...
The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions Steffen Glöckner, Duc N. Tran, Richard J. Ingham, Sabine Fenner, Zoe E. Wilson, Claudio...
View ArticleClik here to view.
Gatifloxacin
GATIFLOXACIN BMS-206584, CG-5501, AM-1155, Zymar, Bonoq, Gatiflo, AM-1155 (±)-1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Gatifloxacin sold...
View ArticleClik here to view.
Sun Kim ……Quality-by-Design Evangelist
Sun Kim QbDWorks.com – Quality by Design for Pharma, Biotech, Medical Devices Dr. Sun K. Kim is a Quality-by-Design Evangelist, transforming how Product Development is executed in the Biologics,...
View ArticleClik here to view.
11-Chloro-1-undecene
11-Chloro-1-undecene Name 11-Chloro-1-undecene Synonyms Name in Chemical Abstracts 1-Undecene, 11-chloro- CAS No 872-17-3 EINECS No Molecular formula C11H21Cl Molecular mass 188.74 SMILES code...
View ArticleClik here to view.
trans-Cinnamamide , (2E)-3-Phenyl-2-propenamide
trans-Cinnamamide/(2E)-3-Phenyl-2-propenamide Name trans-Cinnamamide Synonyms (2E)-3-Phenyl-2-propenamide Name in Chemical Abstracts 2-Propenamide, 3-phenyl-, (2E)- CAS No 22031-64-7 EINECS No...
View ArticleClik here to view.
Pd(II) catalyzed ortho C–H iodination of phenylcarbamates at room temperature...
A novel approach to access ortho iodinated phenols using cyclic hypervalent iodine reagents through palladium(II) catalyzed C–H activation has been developed through weak coordination. The reaction...
View ArticleClik here to view.
Nonanedioic acid, Azelaic acid
Nonanedioic acid Azelaic acid Name Nonanedioic acid Synonyms Azelaic acid Name in Chemical Abstracts Nonanedioic acid CAS No 123-99-9 EINECS No 204-669-1 Molecular formula C9H16O4 Molecular mass...
View ArticleClik here to view.
NMR, 3-[3-(benzoylamino)-4-hydroxylphenyl] propanoic acid
http://www.google.com/patents/WO2008022462A1?cl=en 1 H-NMR Spectrum of Compound 35…………3-[3-(benzoylamino)-4-hydroxylphenyl] propanoic acid 1H-NMR (Acetone-D6) δ: 2.60 (t, 2H, J = 7.4, H- 3), 2.84...
View ArticleClik here to view.
Axitinib
Axitinib (AG013736; trade name Inlyta) is a small molecule tyrosine kinase inhibitor developed by Pfizer. It has been shown to significantly inhibit growth of breast cancer in animal (xenograft)...
View ArticleClik here to view.
Sofosbuvir new patent…WO 2015097605, Mylan
WO 2015097605 Mylan Laboratories Ltd. Process for the preparation of sofosbuvir 02 July 2015 The present disclosure relates to processes for the preparation of sofosbuvir or of its pharmaceutically...
View ArticleClik here to view.
GMP IN AN API PILOT PLANT
GMP……API PILOT PLANT PRESENTATION Pilot plant scaleup techniques used in pharmaceutical manufacturing from Sunil Boreddy Rx Pilot plant and scale-up techniques are both integral and critical to...
View ArticleClik here to view.
CANAGLIFLOZIN
CANAGLIFLOZIN Canagliflozin Canagliflozin is a highly potent and selective subtype 2 sodium-glucose transport protein (SGLT2) inhibitor to CHO- hSGLT2, CHO- rSGLT2 and CHO- mSGLT2 with IC50 of 4.4 nM,...
View ArticleClik here to view.
Trimyristin
Trimyristin Trimyristin is an ester with the chemical formula C45H86O6. It is a saturated fat which is the triglyceride of myristic acid. Trimyristin is a white to yellowish-gray solid that is...
View ArticleClik here to view.
Zydus Cadila Healthcare Ltd, WO 2015102017, lorcaserin
Processes for the preparation of lorcaserin Zydus Cadila Healthcare Ltd WO 2015102017, 09 July2015 Applicants: CADILA HEALTHCARE LIMITED [IN/IN]; Zydus Tower, Satellite Cross Roads Ahmedabad – 380...
View ArticleClik here to view.
Fispemifene for hypogonadism
Fispemifene, HM 101 Fispemifene; UNII-3VZ2833V08; cas 341524-89-8 Molecular Formula: C26H27ClO3 Molecular Weight: 422.94378 g/mol...
View ArticleClik here to view.
What is SBM-TFC-039 an SGLT Inhibitor from Sirona Biochem
A new “flozin” seems to me appearing on the horizon in form of SBM-TFC-039 an SGLT Inhibitor from Sirona Biochem, picked up a list from WO 2012160218, from TFChem…….see link , Sirona Biochem Announces...
View ArticleClik here to view.
Application in Febuxostat synthesis
……….. Facile One-Pot Transformation of Arenes into Aromatic Nitriles under Metal-Cyanide-Free Conditions Abstract Electron-rich arenes bearing methyl or methoxy groups on the aromatic ring were...
View ArticleClik here to view.
ETC-159
ETC-159 Duke-NUS Graduate Medical School; Experimental Therapeutics Centre of Singapore Cysteine palmitoyltransferase porcupine inhibitor Pharmacological inhibition of the Wnt acyltransferase PORCN...
View ArticleClik here to view.
Flow chemistry can make processes greener….Swern oxidation
The Swern oxidation, named after Daniel Swern, is a chemical reaction whereby a primary or secondary alcohol is oxidized to an aldehyde or ketone using oxalyl chloride,dimethyl sulfoxide (DMSO) and an...
View ArticleClik here to view.
Cyclopentene-1,3-dione derivative
the isolated cyclopentenedione derivative may have structure 1a or 1b or even exist as an equilibrium mixture between these two enol forms showing average 1H and 13C NMR spectra due to a proposed...
View Article