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How flow chemistry can make processes greener…………Supercritical fluids
Safe, small scale access to supercritical fluids The ability to safely access high temperatures and pressures in flow reactors has implications not only on the rate of chemical reactions, but also on...
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Heterogeneous catalysis and catalyst recycling
Heterogeneous catalysis and catalyst recycling Heterogeneous catalysis is a type of catalysis in which the catalyst occupies a different phase from the reactants and products. This may refer to the...
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Telescoping multistep reactions
Telescoping multistep reactions The synthesis of fine chemicals sometimes requires multiple reactions and tedious work-up between each step is often necessary. Purification may involve the addition...
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ROSAPROSTOL
Rosaprostol CAS Registry Number: 56695-65-9 CAS Name: 2-Hexyl-5-hydroxycyclopentaneheptanoic acid Additional Names: 9-hydroxy-19,20-bisnorprostanoic acid Manufacturers’ Codes: C-83; IBI-C83...
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Ozanimod, RPC1063
cas 1306760-87-1 Ozanimod, RPC1063 Receptos, Inc. INNOVATOR IUPAC/Chemical name: (S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile...
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Filgotinib
Filgotinib C21H23N5O3S MW425.504 Elemental Analysis: C, 59.28; H, 5.45; N, 16.46; O, 11.28; S, 7.54 1206161-97-8 Cyclopropanecarboxamide,...
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FDA approves flibanserin first treatment for sexual desire disorder
Flibanserin BIMT-17 BIMT-17-BS 1,3-Dihydro-1-(2-(4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)ethyl)-2H-benzimidazol-2-one 167933-07-5 FDA approves first treatment for sexual desire disorder Addyi...
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Gamendazole a novel drug candidate for male contraception.
Gamendazole (E) 3-(1-(2,4-Dichlorobenzyl)-6-(trifluoromethyl)-1H-indazol-3-yl)acrylic Acid trans-3-(1-Benzyl-6-(trifluoromethyl)-1H-indazol-3-yl)acrylic acid)...
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Lusutrombopag….Oral thrombopoietin (TPO) mimetic
Lusutrombopag (E)-3-[2,6-dichloro-4-[[4-[3-[(1S)-1-hexoxyethyl]-2-methoxyphenyl]-1,3-thiazol-2-yl]carbamoyl]phenyl]-2-methylprop-2-enoic acid...
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Benzyl 3-deoxy-3-(3,4,5-trimethoxybenzylamino)-β-L-xylopyranoside
The title compound was synthesized by opening the epoxide of benzyl 2,3-anhydro-β-L-ribopyranoside with 3,4,5-trimethoxybenzylamine (Scheme 1). The three broad peaks in the 1 H-NMR due to one –NH at...
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ASLAN Pharmaceuticals Gains Orphan Designation for Rare Cancer Drug ASLAN001...
(R)-N4-[3-Chloro-4-(thiazol-2-ylmethoxy)-phenyl]-N6-(4-methyl-4,5-dihydro-oxazol-2-yl)-quinazoline-4,6-diamine ASLAN001 , Varlitinib C22H19ClN6O2S Molecular Weight: 466.94 Elemental Analysis: C,...
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NEW PATENT…..DABIGATRAN ETEXILATE MESYLATE, INTERMEDIATES OF THE PROCESS AND...
WO2015124764 ERREGIERRE S.P.A. [IT/IT]; Via Francesco Baracca, 19 I-24060 San Paolo D’argon (IT) Erregierre SpA DABIGATRAN ETEXILATE MESYLATE, INTERMEDIATES OF THE PROCESS AND NOVEL POLYMORPH OF...
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Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis
The synthesis of complex molecules requires control over both chemical reactivity and reaction conditions. While reactivity drives the majority of chemical discovery, advances in reaction condition...
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An introduction to the Prequalification of Active Pharmaceutical Ingredients
An introduction to the Prequalification of Active Pharmaceutical Ingredients The WHO Prequalification of Medicines Programme (PQP) facilitates access to quality medicines through assessment of...
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Cheap and sensitive test for a key prostate cancer marker
The cavitand-coated micro-beads are able to sweep up the amino acid sarcosine from urine samples Cheap and sensitive test for a key prostate cancer marker Supramolecular-coated magnetic beads offer a...
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Chemical synthesis of IL-10 cytokine 90% cheaper than bioproduction, Provepep
Chemical synthesis of IL-10 cytokine 90% cheaper than bioproduction, Provepep By Dan Stanton+, 08-Oct-2015 Chemical synthesis of peptides and proteins can be done at a tenth of the cost of...
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TAK 272, For Hypertension, Takeda’s Next Sartan
TAK 272 C27 H41 N5 O4 . Cl H, 536.106 CAS.1202269-24-6. MonoHCl 1202265-90-4 DIHCL Base cas…1202265-63-1 Metanesulfonate…1202266-34-9 Takeda Pharmaceutical Company Limited, INNOVATOR see...
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MAVATREP, JNJ 39439335,
Mavatrep; UNII-F197218T99; Mavatrep (USAN); JNJ-39439335; 956274-94-5; 2-(2-(2-(2-(4-trifluoromethylphenyl)vinyl)-1H-benzimidazol-5-yl)phenyl)propan-2-ol...
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Tafluprost
isopropyl (5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl}hept-5-enoate, Tafluprost propan-2-yl...
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A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions...
An immobilised monolithic iridium hydrogen transfer catalyst has been developed for use in flow based processing. The monolithic construc thas been used for several redox reductions demonstrating...
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