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Toward a Large-Scale Approach to Milnacipran Analogues Using Diazo Compounds...
The safe use of diazo reagents for the preparation of a key structure in the synthesis of milnacipran analogues is described herein. Using continuous flow technology, the diazo reagent is...
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New Drug Approvals blog by Dr Anthony Crasto hits ten lakh views in 211...
New Drug Approvals hits ten lakh views in 211 countries http://newdrugapprovals.org/ THANKS AND REGARD’S DR ANTHONY MELVIN CRASTO Ph.D amcrasto@gmail.com MOBILE-+91 9323115463 GLENMARK SCIENTIST ,...
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NEW PATENT WO2015188782, METHOD FOR PREPARING SOFOSBUVIR
SOFOSBUVIR NEW PATENT WO2015188782, (WO2015188782) METHOD FOR PREPARING SOFOSBUVIR CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD [CN/CN]; No. 8 Julong North Rd., Xinpu District Lianyungang, Jiangsu...
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MONITORING FLUORINATIONS……Selective direct fluorination for the synthesis of...
. Optimisation and real time reaction monitoring of the synthesis of 2-fluoromalonate esters by direct fluorination using fluorine gas is reported. An assessment of green metrics including atom...
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Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products
Recently, application of the flow technologies for the preparation of fine chemicals, such as natural products or Active Pharmaceutical Ingredients (APIs), has become very popular, especially in...
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Twelve Principles for Drug Optimization
Twelve Principles for Drug Optimization 1. Increasing Potency In the analogue class of the histamine H2-receptor antagonists (cimetidine, nizatidine, ranitidine, roxatidine, and famotidine), an...
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Current Practices of Process Validation for Drug Substances and Intermediates
Process validation includes laboratory optimization, pilot-plant introduction, and process implementation on manufacturing scale, as well as monitoring batches after implementation and continuously...
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Facts, Growth, and Opportunities in Industrial Biotechnology
The revolution in synthetic biology has enabled innovative manufacture of biofuels and the development of biological processes for the manufacture of bulk and fine chemicals. This short review gives...
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WO 2016018024, DAPAGLIFLOZIN, HANMI FINE CHEMICAL CO., LTD, New patent
(S) – propylene glycol and water, 1: 1 crystalline complex PATENT WO2016018024, CRYSTALLINE COMPOSITE COMPRISING DAPAGLIFLOZIN AND METHOD FOR PREPARING SAME HANMI FINE CHEMICAL CO., LTD. [KR/KR];...
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VASICINE, (peganine)
. Vasicine (peganine) is a quinazoline alkaloid. It is the active compound of Justicia adhatoda, after which the chemical is named. Vasicine has been compared to theophylline both in vitro and in...
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BENFOTIAMINE
Benfotiamine S-[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-phosphonooxypent-2-en-3-yl] benzenecarbothioate Benphothiamine; Betivina; Biotamin; Neurostop; Nitanevril;22457-89-2...
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Biocon’s Rosuvastatin Calcium tablets get EU approval to treat hyperlipidemia
Biocon’s Rosuvastatin Calcium tablets get EU approval to treat hyperlipidemia Indian biopharmaceutical company Biocon has received approval from the European Commission for its Rosuvastatin Calcium...
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ONL 1204 a small molecule peptide for Treatment of retinal detachment
OR ONL 1204 CAS 1349038-53-4...
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AVORALSTAT
Avoralstat, BCX4161, CAS 918407-35-9 UNII: UX17773O15 513.5513, C28-H27-N5-O5 2-Pyridinecarboxylic acid,...
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Application of On-Line NIR for Process Control during the Manufacture of...
The transamination-chemistry-based process for sitagliptin is a through-process, which challenges the crystallization of the active pharmaceutical ingredient (API) in a batch stream composed of...
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Catalyst-free thiolation of indoles with sulfonyl hydrazides for the...
Catalyst-free thiolation of indoles with sulfonyl hydrazides for the synthesis of 3-sulfenylindoles in water Green Chem., 2016, Advance Article DOI: 10.1039/C6GC00313C, Communication Yu Yang, Sheng...
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Pd(II) pincer type complex catalyzed tandem C-H and N-H activation of...
Pd(II) pincer type complex catalyzed tandem C-H and N-H activation of acetanilide in aqueous media: a concise access to functionalized carbazoles in a single step Green Chem., 2016, Advance Article...
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Crystallization of Artemisinin from Chromatography Fractions of Artemisia...
Crystallization is an inevitable step in the purification of artemisinin either from the plantArtemisia annua or from reaction mixtures of semisynthetically produced artemisinin. Rational design of...
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Efficient formation of nitriles in the vapor-phase catalytic dehydration of...
Efficient formation of nitriles in the vapor-phase catalytic dehydration of aldoximes Green Chem., 2016, Advance Article DOI: 10.1039/C6GC00384B, Paper Daolai Sun, Eisyun Kitamura, Yasuhiro Yamada,...
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