Clik here to view.
Nanopalladium-catalyzed conjugate reduction of Michael acceptors –...
Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow Green Chem., 2016, Advance Article DOI: 10.1039/C5GC02920A, Communication Anuja Nagendiran, Henrik Sorensen,...
View ArticleClik here to view.
ITI 214
ITI 214 IC200214; ITI-214 (6aR,9aS)-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(phenylamino)-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4-(2H)-one phosphate...
View ArticleClik here to view.
Breaking the symmetry of dibenzoxazines: a paradigm to tailor the design of...
Green Chem., 2016, Advance Article DOI: 10.1039/C5GC03102H, Paper L. Puchot, P. Verge, T. Fouquet, C. Vancaeyzeele, F. Vidal, Y. Habibi Asymmetric di-benzoxazine monomers from naturally occurring...
View ArticleClik here to view.
An Improved Process for the Preparation of Tenofovir Disoproxil Fumarate
Tenofovir Disoproxil Fumarate PAPER The current three-step manufacturing route for the preparation of tenofovir disoproxil fumarate (1) was assessed and optimized leading to a higher yielding,...
View ArticleClik here to view.
New FDA Guidance on Completeness Assessements for Type II API Drug Master Files
Since 1st October 2012, special regulations have been applying to the US Type II Drug Master Files. This year in February, the FDA published a new Guidance for Industry. Read here what the DMF holder...
View ArticleClik here to view.
Second Revision of USP Chapter Injections and Implanted Drug Products...
After the revision of the General Chapter on quality testing of sterile medicinal products in the US American Pharmacopoeia had already been announced last year in the USP 38-NF 33, the USP is...
View ArticleClik here to view.
ECA releases Version 18 of GMP Guideline Manager
How to access ten thousand pages of GMP Guidelines from FDA, EMA, ICH, PIC/S, ICH, WHO and many other organisations worldwide? You can print them or purchase hundreds of booklets. Or, alternatively,...
View ArticleClik here to view.
Already 13 EMA GMP Non-compliance Reports in 2016 published
EudraGMDP is the central database for GMP and GDP compliance. Inspections which have been performed by any of the EU member state inspectorates are published in the database. Please get the details...
View ArticleClik here to view.
Trioxacarcin A
Trioxacarcin A, DC-45A CAS No. 81552-36-5 Molecular FormulaC42H52O20 Average mass876.850 Da...
View ArticleClik here to view.
Trichloroacetic Acid Removal by a Reductive Spherical Cellulose Adsorbent
Chemical Research in Chinese Universities Vol.32 No.1 February 2016 2016 Vol. 32 (1): 0-0 [Abstract] ( 20 ) [HTML 1KB] [PDF 2198KB] ( 11 ) A novel spherical cellulose adsorbent with amide and...
View ArticleClik here to view.
Cycloaddition of epoxides and CO2 catalyzed by bisimidazole-functionalized...
Cycloaddition of epoxides and CO2 catalyzed by bisimidazole-functionalized porphyrin cobalt(III) complexes Green Chem., 2016, Advance Article DOI: 10.1039/C6GC00370B, Paper Xu Jiang, Faliang Gou,...
View ArticleClik here to view.
A pot-economical and diastereoselective synthesis involving catalyst-free...
Green Chem., 2016, Advance Article DOI: 10.1039/C6GC00497K, Communication Xiaofeng Zhang, Sanjun Zhi, Wei Wang, Shuai Liu, Jerry P. Jasinski, Wei Zhang A pot-economical synthesis involving two [3 +...
View ArticleClik here to view.
Phytochemical compounds or their synthetic counterparts? A detailed...
Green Chem., 2016, 18,1807-1818 DOI: 10.1039/C6GC00090H, Paper Elisabetta Zerazion, Roberto Rosa, Erika Ferrari, Paolo Veronesi, Cristina Leonelli, Monica Saladini, Anna Maria Ferrari LCA of the...
View ArticleClik here to view.
FDA approves new treatment for inhalation anthrax, Anthim (obiltoxaximab)...
Anthim (obiltoxaximab) ETI-204 March 21, 2016 Release http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm491470.htm On Friday, March 18, the U.S. Food and Drug Administration approved Anthim...
View ArticleClik here to view.
BRIVARACETAM
BRIVARACETAM, UCB-34714 (2S)-2-[(4R)-2-oxo-4-propylpyrrolidin-1-yl]butanamide (2S)-2-[(4R)-2-Oxo-4-propyl-1-pyrrolidinyl]butanamide 1-Pyrrolidineacetamide, α-ethyl-2-oxo-4-propyl-, (αS,4R)- CAS...
View ArticleClik here to view.
Dipeptide-Based Metabolic Labeling of Bacterial Cells for Endogenous Antibody...
The number of antibiotic-resistant bacterial infections has increased dramatically over the past decade. To combat these pathogens, novel antimicrobial strategies must be explored and developed. We...
View ArticleClik here to view.
Palladium-Catalyzed Aerobic Oxidative Coupling of o-Xylene in Flow: A Safe...
Herein, the first continuous cross-dehydrogenative homocoupling of an unactivated arene using oxygen as sole oxidant is reported. Employing microreactor technology which enables the use of elevated...
View ArticleClik here to view.
PF-06747775 (Pfizer) Third generation covalent EGFR inhibitors
PF-06747775 (Pfizer) PF06747775; PF06747775; PF 06747775; PF6747775; PF 6747775; PF6747775. PFE-X775...
View ArticleClik here to view.
罗西替尼 роцилетиниб روسيليتينيب Rociletinib, CO-1686. Third generation covalent...
Rociletinib (CO-1686) AVL-301,CNX-419 Celgene (Originator) , Clovis Oncology N-(3-{[2-{[4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl]amino}-5- (trifluoromethyl)pyrimidin-4-yl]amino}phenyl)prop-2-enamide...
View ArticleClik here to view.
EGF 816 , Nazartinib
EGF 816, Nazartinib EGF-816; EGFRmut-TKI EGF816 Novartis Ag innovator (R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide...
View Article