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Oliceridine
Oliceridine N-[(3-methoxythiophen-2-yl)methyl]-2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]ethan-1-amine [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-...
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Marksans Pharma gets FDA nod for its ANDA for metformin hydrochloride...
FDA OK for India’s Marksans Pharma Generic Version of Type 2 Diabetes Drug Read at FDA OK for India’s Marksans Pharma Generic Version of Type 2 Diabetes Drug SEE ALSO Diabetes Drug: Latest...
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EMA publishes finalised Process Validation Guideline for Biotech Products
Approximately two years ago the EMA published a draft guideline on process validation for the manufacture of biotech products. Now the final guideline has been published under the title “Guideline...
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Quality Documentation of API mix in the Marketing Authorisation Procedure
For different reasons, the manufacture of APIs may sometimes require adding excipients. In the context of an authorisation procedure, this practice reveals to be problematic. Read more here about the...
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Processes for Constructing Homogeneous Antibody Drug Conjugates
Antibody drug conjugates (ADCs) are synthesized by conjugating a cytotoxic drug or “payload” to a monoclonal antibody. The payloads are conjugated using amino or sulfhydryl specific linkers that react...
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Sun Pharma and Merck & Co. Inc. Enter into Licensing Agreement for Tildrakizumab
Tildrakizumab (MK-3222) Company Merck & Co. Inc. Description Anti-IL-23 antibody Molecular Target Interleukin-23 (IL-23) Mechanism of Action Antibody Therapeutic Modality Biologic: Antibody Latest...
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A New Antibiotic...
(E)-3-(3-Carboxyphenyl)-2-(4-ethynylstyryl)quinazolin-4(3H)-one (E)-3-(2-(4-Cyanostyryl)-4-Oxoquinazolin-3(4h)-Yl)benzoic Acid; 1624273-22-8 CAS NA SALT 1624273-21-7 CAS INNOVATORS University Of...
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Development of a Safe and Robust Process for the Large-Scale Preparation of a...
The large-scale synthesis of ethyl 4-bromocyclohex-3-enecarboxyalate, using a mild brominating reagent derived from triphenyl phosphite and bromine, is reported. The development and comparison of both...
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Potential of Homogeneous Pd Catalyst Separation by Ceramic Membranes....
Successful chemical production of molecules while simultaneously reducing the environmental impact of the process relies not only on more efficient reactions but also on developments in reactor and...
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Continuous Flow Magnesiation of Functionalized Heterocycles and Acrylates...
Knochel’s group in Munich have recently disclosed how a variety of functionalised heterocycles and sensitive acrylates can be rapidly magnesiated and subsequently quenched with an electrophile...
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CADROFLOXACIN
Cadrofloxacin , CS 940 3-Quinolinecarboxylic acid, 1-cyclopropyl-8-(difluoromethoxy)-6-fluoro-1,4-dihydro-7-[(3S)-3-methyl-1-piperazinyl]-4-oxo-, hydrochloride (1:1) UNII-1YOQ7J9ACY; 153808-85-6;...
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Nolatrexed Dihydrochloride
Nolatrexed NDA Filed in china A thymidylate synthase inhibitor potentially for the treatment of hepatocellular carcinoma and nasopharyngeal cancer. AG-337 CAS No. 147149-76-6 (free) free form data...
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Arbaclofen
Arbaclofen placarbil (3R)-3-(4-chlorophenyl)-4-[[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino]butanoic acid NDA filed A GABA (B) receptor agonist potentially for the treatment of muscle...
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Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifolia
Figure 2 Selected key HMBC (1H 13C) and NOESY (1H 1H) correlations for ixorine (1). Figure 1 Structures of compounds 1–4 isolated from the branches of I. brevifolia. Ixorine (1) HRESIMS m/z, calcd.:...
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Lupin to co-market Novartis’ asthma drug in India
Lupin to co-market Novartis’ asthma drug in India BS B2B Bureau | Mumbai April 12, 2016 Last Updated at 10:27 IST Novartis Healthcare will continue to market Sequadra (indacaterol/glycopyrronium...
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Multibiphenyl A, New biphenyls from Garcinia multiflora.
Figure 2 Selected HMBC (H→C) and 1H-1H correlation spectroscopy (COSY) (–) correlations of 1. Compound 1 was obtained as a pale yellow gum. The molecular formula was determined to be C20H22O6 from...
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Buthionine Sulphoximine
Buthionine Sulphoximine NDA Filed in china A gamma-glutamylcysteine synthetase inhibitor potentially for the treatment of solid tumors. NSC-326231; BSO CAS No. 5072-26-4 BUTHIONINE SULFOXIMINE;...
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EMA’s new Draft Guideline on the Sterilisation of Medicinal Products, APIs,...
For medicinal products administrated in sterile form, the process to reduce the microbial level is a critical manufacturing step with regard to quality. The EMA has recently published the draft of a...
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USP publishes draft of a new general chapter for plastic components used in...
In the Pharmacopoeial Forum (PF) 42(3) (May-June 2016) the USP General Chapters – Packaging and Distribution Expert Committee proposes a new general chapter <661.3> Plastic Components and...
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APIs from Legitimate and Reliable Sources
APIs from Legitimate and Reliable Sources 1. Introduction Counterfeit and sub-standard APIs are increasingly present. Not only are they a fact of non-compliance but also they form a serious and...
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