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Illegal Drugs in Dietary Supplements
Illegal Drugs in Dietary Supplements Forbidden stimulant oxilofrine found in various dietary supplements sold in the USA Read more...
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Printing with Collagen
Printing with Collagen Addition of collagen to hydrogels in 3D printing improves stem cell differentiation in osteogenesis Read more...
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Dihydrobenzofuran Neolignans
Figure 1 Structures of dihydrobenzofuran neolignans 2a and 2b. Scheme 1 (i) Ag2O, (CH3)2CO:C6H6 3:5, r.t., 20 h (2a: 36% yield; 2b: 43% yield). Figure 3 Main nuclear Overhauser effect (NOE)...
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Palladium- and Nickel-Catalyzed Amination of Aryl Fluorosulfonates
Examples of the palladium- and nickel-catalyzed amination of aryl fluorosulfonates with aromatic and alkyl amines are described. Aniline is coupled to a diverse series of aryl fluorosulfonates...
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Teslaphoresis of Carbon Nanotubes
This paper introduces Teslaphoresis, the directed motion and self-assembly of matter by a Tesla coil, and studies this electrokinetic phenomenon using single-walled carbon nanotubes (CNTs)....
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Solvates, Salts, and Cocrystals: A Proposal for a Feasible Classification System
The design of pharmaceutical cocrystals has initiated widespread debate on the classification of cocrystals. Current attempts to classify multicomponent crystals suffer from ambiguity, which has led...
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Optimization, Production, and Characterization of a...
We have synthesized and characterized a novel phosphorothioate CpG oligodeoxynucleotide (CpG ODN)-Ficoll conjugated nanoparticulate adjuvant, termed DV230-Ficoll. This adjuvant was constructed from an...
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BMS-520, a Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist
BMS-520 CAS: 1236188-38-7 MF: C23H17F3N4O4 MW: 470.1202 Synonym: BMS-520; BMS 520; BMS520. INNOVATOR Bristol-Myers Squibb Company INVENTORS Scott Hunter Watterson, Alaric J. Dyckman,William J. Pitts,...
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Letermovir, AIC 246
Letermovir, MK 8828, AIC 246 2-[(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4H-quinazolin-4-yl]acetic acid CAS 917389-32-3 Letermovir; UNII-1H09Y5WO1F;...
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Ethyl 1-(7-chloroquinolin-4-yl)-5-methyl-1H-1,2,3-triazole-4-carboxylate
Scheme 1 General scheme of the reaction. Scheme 2 General procedure for the synthesis of 7-chloroquinoline-1,2,3-triazoyl carboxylates To a solution of 4-azido-7-chloroquinoline 1 (0.3 mmol,...
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ICH M8 “Specification for Submission Formats for eCTD”
This additional specification describes the way files should be constructed for inclusion in the eCTD. Key Points: It is not necessary to use a product from Adobe or from any specific company to...
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ICH Q3D Implementation Working Group (IWG)—Training Modules
ICH Q3D Implementation Working Group (IWG)—Training Modules ICH Q3D is a complex guideline. The overall requirement in terms of control is clear—there are defined limits for some 24 elements, and...
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MK-7145
MK-7145, cas 1255204-84-2 1(3H)-Isobenzofuranone, 5,5′-(1,4-piperazinediylbis((1R)-1-hydroxy-2,1-ethanediyl))bis(4-methyl- MF C26 H30 N2 O6, Molecular Weight 466.53 1(3H)-Isobenzofuranone,...
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MK 8718
MK 8718 Cas 1582729-24-5 (free base); 1582732-29-3 (HCl). MF: C30H30ClF6N5O4 MW: 673.1891 INNOVATOR Merck Sharp & Dohme Corp., Merck Canada Inc....
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PDE4 Inhibitors, Boehringer Ingelheim Pharmaceuticals
R CONF SHOWN BI ? (R)-2-(4-(4-Chlorophenoxy)piperidin-1-yl)-4-((tetrahydro-2H-pyran-4-yl)amino)-6,7-dihydrothieno[3,2-d]pyrimidine 5-Oxide C22 H27 Cl N4 O3 S, 462.99 CAS 1910076-27-5...
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FDA´s new policy regarding grouping of supplements for CMC changes
The US Food and Drug Administration’s (FDA) Office of Pharmaceutical Quality (OPQ) released a new document outlining how supplements can be grouped together and submitted concurrently for the same...
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EMA publishes Q&A on data required for sterilized primary packaging materials...
The European Medicines Agency, EMA, recently published questions and answers on what data is required for sterilisation processes of primary packaging materials subsequently used in an aseptic...
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ICH M7
ICH M7 Although relatively quiet in terms of any specific regulatory activities, the last 6 months have seen a plethora of publications that are associated with the ICH M7 guideline. Prominent...
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PDE4 inhibitor , Sumitomo Dainippon Pharma Company
2-[2-Methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-benzimidazol-5-yl]-1,3-benzoxazole Hemifumarate Sumitomo Dainippon Pharma Company, CAS FREE FORM 1256966-65-0 Benzoxazole,...
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Chemical Engineering in China
Chemical Engineering in China Current trends of chemical engineering in the world’s biggest chemical market Read more...
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