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Quisapride Hydrochloride
Quisapride Hydrochloride (R) – quinuclidine-3-5 – ((S) -2 – (( 4 – amino-5-chloro-2-ethoxy benzoylamino) methyl) morpholino) hexanoate IND Filed china A 5-HT4 agonist potentially for the treatment of...
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Eosin Y catalyzed difunctionalization of styrenes using O2 and CS2: a direct...
Green Chem., 2016, Advance Article DOI: 10.1039/C6GC00924G, Paper Arvind K. Yadav, Lal Dhar S. Yadav An efficient, one-pot, highly regioselective synthesis of 1,3-oxathiolane-2-thiones from styrenes,...
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Nanopalladium-catalyzed conjugate reduction of Michael acceptors –...
Green Chem., 2016, 18,2632-2637 DOI: 10.1039/C5GC02920A, Communication Anuja Nagendiran, Henrik Sorensen, Magnus J. Johansson, Cheuk-Wai Tai, Jan-E. Backvall A continuous-flow approach towards the...
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FDA approved a switchover from batch to the new technology for production of...
Above is an Illustration example, FDA urges companies to get on board with continuous manufacturing The FDA gave Johnson & Johnson’s ($JNJ) Janssen drug unit the thumbs up last week for the...
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Antimycobacterial Agents
Styryl Hydrazine Thiazole Hybrids Will be updated………kindly email amcrasto@gmail.com DATA ABOUT Dehydrozingerone Dehydrozingerone; Feruloylmethane; 1080-12-2;...
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CFI-402257
CFI-402257 N-cyclopropyl-4-(7-((((1s,3s)-3-hydroxy-3-methylcyclobutyl)methyl)amino)-5-(pyridin-2-yloxy)pyrazolo[1,5-a]pyridin-3-yl)-2-methylbenzamide N-cyclopropyl-4-(7-( (((Is,...
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WHO issues revised Guideline on HVAC Systems
The World Health Organization (WHO) recently issued a guideline for commenting which describes the requirements for HVAC systems for the manufacture of non-sterile forms. As most guidelines on this...
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EU GMP Annex 1 Revision 2016 – what does the pharmaceutical industry expect?
Dr Friedrich Haefele, Vice President Fill & Finish Biopharma at Boehringer Ingelheim Dr Friedrich Haefele, Vice President Fill & Finish Biopharma at Boehringer Ingelheim talked in his keynote...
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Crisil rings warning bell for pharma on US slowdown
Companies like Dr. Reddy’s Laboratories and Sun Pharma derive close to 60% of their revenue from exports to the US. Lupin too, gets 45% of its revenue from generic formulation sales to the US, while...
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SETIPIPRANT
Setipiprant, KYTH-105 CAS 866460-33-5 2-(2-(1-naphthoyl)-8-fluoro-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)acetic acid...
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Flow synthesis of Fluoxetine
Scheme 1: Flow synthesis of fluoxetine (46). PIC CREDIT, The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry, Marcus Baumann and Ian R. Baxendale, Beilstein J....
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Flow approach towards AZD 6906
Scheme 1: Flow approach towards AZD6906 (65). PIC CREDIT, The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry, Marcus Baumann and Ian R. Baxendale, Beilstein J....
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FDA approves new diagnostic imaging agent FLUCICLOVINE F-18 to detect...
FLUCICLOVINE F-18 Cyclobutanecarboxylic acid, 1-amino-3-(fluoro-18F)-, trans- [ Molecular FormulaC5H818FNO2 Average mass132.124 Da Axumin (fluciclovine F 18) fluciclovinum (18F) GE-148 NMK36...
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[F-18](2S,4S)-4-(3-Fluoropropyl)glutamine
[F-18](2S,4S)-4-(3-Fluoropropyl)glutamine CAS 1196963-79-7 MF C8 H15 F N2 O3 Heptanoic acid, 2-amino-4-(aminocarbonyl)-7-(fluoro-18F)-, (2S,4S)- [18F](2S,4S)-4-FPGln...
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Rovatirelin Hydrate
Rovatirelin Hydrate, S-0373, Rovatirelin, RN: 204386-76-5 UNII: 9DL0X410PY...
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Difelikefalin
Difelikefalin, CR-845; MR-13A-9; MR-13A9 4-amino-1- (D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl) piperidine-4-carboxylic acid Phase III C36H53N7O6, 679.40573 Originator Ferring Pharmaceuticals...
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[18F]AMG 580
[18F]AMG 580 CAS 1879904-74-1 MF C26 H24 F N5 O3 NOTE………CAS OF AMG 580 IS 1227067-71-1, WITHOUT 18F AMG 580...
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GSK 6853
GSK 6853 CAS 1910124-24-1 C22 H27 N5 O3, 409.48 Benzamide, N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxy- (R)-N-(1 ,3-...
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Targeted Nanoparticles for the Delivery of Novel Bioactive Molecules to...
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor prognosis and limited therapeutic options. Therefore, there is an urgent need to identify new, safe, and targeted...
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CCT 245737
CCT 245737 CAS:1489389-18-5 M.Wt: 379.34 Formula: C16H16F3N7O 2-Pyrazinecarbonitrile, 5-[[4-[[(2R)-2-morpholinylmethyl]amino]-5-(trifluoromethyl)-2-pyridinyl]amino]-...
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