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4-(2-Hydroxyethyl)-1,3-dihydro-2H-indol-2-one
13C NMR (DMSO-d6, 100 MHz): δ = 35.2, 36.8, 61.5, 107.4, 122.5, 125.4, 127.8, 136.1, 143.8, 176.9; 1H NMR 1H NMR (DMSO-d6, 400 MHz): δ = 2.64 (t, J = 6.8 Hz, 2H), 3.44 (s, 2H), 3.59 (q, J = 6.8 Hz,...
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A deeper shade of green: inspiring sustainable drug manufacturing
Green and sustainable drug manufacturing go hand in hand with forward-looking visions seeking to balance the long-term sustainability of business, society, and the environment. However, a lack of...
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Overcoming barriers to green chemistry in the pharmaceutical industry – the...
Scheme 1. Pfizer’s Commercial Synthesis of sildenafil citrate (Viagra™) “Green chemistry” refers to the promotion of safe, sustainable, and waste-minimizing chemical processes. The...
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Towards automation of chemical process route selection based on data mining
A methodology for chemical routes development and evaluation on the basis of data-mining is presented. A section of the Reaxys database was converted into a network, which was used to plan...
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A catalyst-free 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines and...
We have reported herein a catalyst-free 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines and 3-nitroindoles by which a series of five-ring-fused tetrahydroisoquinolines featuring an...
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Methyl (Z)-11-[(3-Hydroxy)propylidene]-6,11-dihydrobenz[b,e]oxepin-2-acetate
E/Z WO2014147647 White solid; Ή NMR (200 MHz, CDC13 + CC14): δ 2.38-2.49 ( m,0.8H, E- Form), 2.63-2.73 ( m,1.2H, Z-Form), 3.53 (s, 2H), 3.68 (s, 3H), 3.75 (m, 0.8H, E-Form), 3.81 (t, J=6.3 Hz, 1.2H),...
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Crystallization and relaxation dynamics of amorphous loratadine under...
CrystEngComm, 2017, 19,335-345 DOI: 10.1039/C6CE01645F, Paper Ruimiao Chang, Qiang Fu, Yong Li, Mingchan Wang, Wei Du, Chun Chang, Aiguo Zeng In this paper, four amorphous samples of loratadine were...
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[3 + 2] Dipolar Cycloadditions in Flow Reactors
FLOW CHEMISTRY ILLUSTRATION Flow chemistry is also known as continuous flow or plug flow chemistry. It involves a chemical reaction run in a continuous flow stream. The process offers potential for...
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Amtolmetin guacil, амтолметин гуацил , أمتولمتين غواسيل , 呱氨托美丁
Amtolmetin guacil, ST-679, MED-15, Eufans CAS 87344-06-7 UNII: 323A00CRO9, Molecular Formula, C24-H24-N2-O5, Molecular Weight, 420.463, 2-Methoxyphenyl...
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Drug Patent expiry in 2017
“ALL FOR DRUGS” CATERS TO EDUCATION GLOBALLY, No commercial exploits are done or advertisements added by me. This article is a compilation for educational purposes only. P.S. : The views expressed...
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An Improved Process for Pioglitazone and Its Pharmaceutically Acceptable Salt
Improved synthetic approach: route A (feasibility) and B (after optimization) Rakeshwar Bandichhor Ph.D. FRSC, CChem, SSWB,BB,MB Director at Dr. Reddy’s Laboratories, Vice-Chair, ACS-India Chapter...
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FDA publishes Final Guideline on GMP for Combination Products
In the beginning of 2015 the FDA has published a draft guideline about GMP for Combination Products. Now the final version has been published. What are the differences between the draft and the...
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EMA publishes Q&A on Health Based Exposure Limits – Does the 1/1000 dose...
In 2014 the European Medicines Agency (EMA) issued the Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared...
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Thailand Drug regulatory Update, Take a peep
http://www.fda.moph.go.th/eng/index.stm [PDF]Regulatory Requirement for the Approval of generic Drug in Thailand … www.jpsbr.org/index_htm_files/JPSBR14RV4029.pdf Apr 13, 2014 – Thailand has its own...
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Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a...
Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement Green Chem., 2017, Advance Article DOI: 10.1039/C6GC03123D, Paper Maurice A....
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Telcagepant Revisited
Telcagepant, MK-0974 Molecular FormulaC26H27F5N6O3 Average mass566.523 Da 1-piperidinecarboxamide,...
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One-Pot Reductive Cyclisations of Nitroanilines to Imidazoles
Hana and co-workers ( Synlett 2010, 18, 2759−2764) from Genentech have developed a single-step procedure for conversion of 2-nitro aromatic amines to benzimidazoles. Addition of ammonium chloride...
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1-Bromo-4-fluoro-2-((2-iodobenzyl)oxy)benzene
1-Bromo-4-fluoro-2-((2-iodobenzyl)oxy)benzene CAS 1161931-51-6 Mp 89.8–92.3 °C. IR (neat, ATR): 3072 (w), 1482 (s), 1451 (s), 1294 (s), 1294 (s) cm–1. 1H NMR (399 MHz, DMSO-d6) δ 5.12 (s, 2H), 6.81...
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Dimethyl 4,4′-(Benzylazanediyl)(2E,2′E)-bis(but-2-enoate)
Dimethyl 4,4′-(Benzylazanediyl)(2E,2′E)-bis(but-2-enoate) IR (CHCl3): ν = 758, 1215, 1278, 1437, 1660, 1720, 2806, 2953, 3020, 3421 cm–1; 13C NMR (CDCl3, 100 MHz) δ: 51.53, 53.42, 58.37, 122.66,...
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2,2′-(1-(tert-Butoxycarbonyl)pyrrolidine-3,4-diyl)diacetic Acid
2,2′-(1-(tert-Butoxycarbonyl)pyrrolidine-3,4-diyl)diacetic Acid 2,2′-(1-(tert-Butoxycarbonyl)pyrrolidine-3,4-diyl)diacetic Acid as a white solid. Mp: 162–163 °C, % purity: 94.09% (HPLC); 1H NMR...
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